Structure-driven approaches to tackle important problems in infectious disease

Structural biology is a powerful tool for understanding how microbes interact with host factors to promote infection, and how complex macromolecular machines drive processes important for pathogen replication and host invasion.  Using a range of techniques, from X-ray crystallography and cryoelectron microscopy (cryo EM) through microbial genetics and biochemistry, we are unraveling the inner workings of the bacterial outer membrane and the complex, harpoon-like invasion machinery of a large family of eukaryotic intracellular pathogens.